Growth Factors
IGF-1 analogues, mechano-growth factor and myostatin-pathway compounds.
5 compounds
ACE-031
Growth FactorsRamatercept · ActRIIB-Fc
Myostatin and activin decoy receptor; human trials were halted over bleeding side effects.
- Dose
- 1–3 mg
- Frequency
- Once weekly
- Half-life
- 12.5 days
Early human
Follistatin 344
Growth FactorsFST-344 · FS-344
Activin- and myostatin-binding protein run in short daily courses; data are animal-only.
- Dose
- 50–200 mcg
- Frequency
- Once daily
- Half-life
- 1 h
Animal only
IGF-1 DES
Growth FactorsDES(1-3)IGF-1 · IGF-1 DES(1-3)
Truncated IGF-1 analogue with roughly 10x potency and a 20-30 minute window of action.
- Dose
- 50–150 mcg
- Frequency
- Once daily
- Half-life
- 24 min
Animal only
IGF-1 LR3
Growth FactorsLong R3 IGF-1 · LR3 IGF-1
Modified IGF-1 that evades its binding proteins, making it far more potent than the native hormone.
- Dose
- 20–80 mcg
- Frequency
- Once daily
- Half-life
- —
Animal only
PEG-MGF
Growth FactorsPegylated MGF · MGF
PEGylated IGF-1Ec E-peptide used after training to extend satellite-cell signalling.
- Dose
- 100–400 mcg
- Frequency
- 2x weekly
- Half-life
- —
Animal only
